Can I tell the difference between a lab-created gemstone and a mined gemstone?

Unless you're a certified gemologist with a powerful microscope, you won't be able to tell the difference between a Chatham lab-created gemstone and mined gemstone. Diamond and gem grading labs hold samples of lab-grown gems that give them the ability to distinguish the difference for fraud purposes. Other than this, their visual, physical, chemical, and atomic makeup is identical.